I can relate to this one a little.
As per the instructions, I wrote notes as to why I chose each nerd.
My list of movies for the showdown "Nerdvember".
This one doesn't have "nerdy in the same way as the originals, but Holtzmann seems to be the sciencey one of the group, creating gadgets and such.
Mark Watney is awesome. He scienced the sh** out of Mars and survived on a barren planet for over a year!
Jesse Eisenberg's portrayal of Mark Zuckerberg was a great twist on the a-hole type character, making him into a smart (and somewhat legalistic) genius.
Without Jane Foster, Thor probably would have gotten arrested and put into a mental asylum. She is the scientific ground of this fantasy movie, and she does so wonderfully.
Alan Turing, the nerd who changed the tide of World War II. If that doesn't impress you, you must be hard to impress.
I suppose you could classify Newt Scamander as a nerd, about magical beasts, at least. It was his extensive knowledge of these creatures he'd studied that saved the Muggle world from discovering the existence of wizardry.
Another a-hole character, like Zuckerberg in The Social Network, except with a less redeeming character arc. That's what happens when you base the character more off of real life, I guess.